The Nationwide Kidney Basis Assertion about INVOKANA® (Canagliflozin)
New York, NY–Sept. 30, 2019— “The Janssen Pharmaceutical Firms of Johnson & Johnson introduced at present that their drug INVOKANA® (Canagliflozin) has been authorized by the U.S. Meals and Drug Administration (FDA) to scale back the chance of end-stage kidney illness (ESKD) and cardiovascular occasions in sufferers with Kind 2 diabetes and continual kidney illness (CKD). It’s the first new remedy for diabetic kidney illness (DKD) to be authorized by the FDA in many years.”
“The Nationwide Kidney Basis applauds Janssen for bringing forth this new remedy and urges sufferers to debate the implications of this new choice with their healthcare professionals.”
“Earlier this 12 months, NKF introduced collectively a gaggle of clinicians, researchers, sufferers and FDA consultant for a two-day, workshop titled ‘The Role of the Kidney and SGLT2 in Glucose Homeostasis and Kidney Disease.
’ The American Journal of Kidney Ailments
will publish sooner or later a abstract of the suggestions from the workshop. A number of initiatives to tell sufferers and healthcare professionals will quickly be launched because of the workshop.”
“Diabetes and CKD are widespread and complicated issues, which regularly co-exist, and every are related to a number of comorbid situations and better danger for mortality. SGLT2s are proteins discovered within the kidneys which are vital within the reabsorption of glucose by the kidneys. INVOKANA, a SGLT2 inhibitor that has been used for glycemic management in folks with diabetes by inhibiting renal reabsorption of glucose, has now been proven to scale back the chance of kidney failure and coronary heart illness on this inhabitants.”
is a key danger issue for chronic kidney disease
, and accounts for 44 percent of all end stage renal disease cases
. Nonetheless lower than 40 p.c of these with diabetes are fully assessed for kidney illness. Two easy checks, an eGFR
(which assesses kidney perform) and an ACR
(which assesses kidney injury) can diagnose kidney illness, and these checks outcomes are additionally robust predictors of cardiovascular danger. For details about CKD, diabetes and cardiovascular danger, see NKF’s complete ‘Chronic Kidney Disease Change Package: Inhabitants Well being Methods for Cardiovascular and Kidney Illness Danger Discount
for clinicians and public well being practitioners introduced in January 2019.”
Kidney Illness Information
In america, 37 million adults are estimated to have chronic kidney disease
—and most aren’t conscious of it. 1 in three American adults are in danger for continual kidney illness. Risk factors for kidney disease
, high blood pressure
, heart disease
, weight problems and household historical past. Folks of African American, Hispanic, Native American, Asian or Pacific Islander descent are at elevated danger for creating the illness. African Individuals are three instances extra possible than Whites, and Hispanics are practically 1.5 instances extra possible than non-Hispanics to develop finish stage renal illness (kidney failure).
The Nationwide Kidney Basis (NKF) is the biggest, most complete and longstanding group devoted to the attention, prevention and remedy of kidney illness. For extra details about NKF go to www.kidney.org.