Modifications in ache sensitization and depressive signs might partially mediate discount in knee pain after substantial weight reduction in morbidly overweight people with knee ache, in accordance with research outcomes printed in Arthritis & Rheumatology.
On this research, 75 morbidly overweight sufferers with frequent knee ache had been assessed for bone marrow lesions, synovitis evaluated on magnetic resonance imaging (MRI), stress ache threshold, the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) Index rating, and the presence of depressive signs with the Middle for Epidemiologic Research Despair Scale (CES-D) previous to bariatric surgical procedure (n=47) or medical weight administration (n=28) and 1 yr after the intervention.
On this cohort, 53.three% of people misplaced ≥20% weight within the first yr and 75% achieved minimal clinically necessary distinction (MCID) in ache enchancment (ie, ≥18% on the WOMAC ache). In people who misplaced <20% weight, 34.three% achieved MCID.
Sufferers who misplaced ≥20% weight vs <20% had been discovered to have elevated odds of MCID ache enchancment in the event that they skilled modifications within the following: patella ache threshold (odds ratio [OR], 1.62-fold; 95% CI, zero.89-2.75-fold change; 62% elevated odds), wrist ache threshold (OR, 1.15- fold; 95% CI, zero.77-1.77-fold change; 15% elevated odds), and depressive signs (OR, 1.22-fold; 95% CI, zero.77-1.87-fold; 22% elevated odds). Enhancements in ache weren’t discovered to be mediated by MRI modifications in bone marrow lesions or synovitis.
Examine limitations embrace a comparatively small pattern that was virtually fully composed of ladies.
“Our findings recommend that modifications in ache sensitization and in depressive signs mediate partially the knee ache enchancment skilled by these present process substantial weight reduction, particularly following bariatric surgical procedure,” famous the research investigators. “This implies that ache sensitization and depressive signs might be a promising goal for future intervention research in these with power knee ache.”
Jafarzadeh SR, Neogi T, Li JS, et al. Mediating role of bone marrow lesion, synovitis, pain sensitization, and depressive symptoms on knee pain improvement following substantial weight loss [published online September 28, 2019]. Arthritis Rheumatol. doi:10.1002/artwork.41125